ABSTRACT
Objective: To explore the clinicopathological features of patients with carcinomatous change of breast intraductal papilloma as well as the treatment protocols and the survival. Methods: The medical records and follow-up data of 151 patients with carcinomatous change of breast intraductal papilloma admmited to Cancer Hospital of Tianjin Medical University from November 1998 to July 2011 were retrospectively analyzed. These patients were categorized into two subgroups by pathology: carcinomatous change which was confined within duct (n = 113, 74.8%) and infiltrative carcinomatous change (n = 38, 25.2%). The clinicopathological features, the treatment protocols and the survival were analyzed. Results: The rate of nipple discharge in patients with infiltrative carcinomatous change was higher than that in patients with carcinomatous change confined within duct (P = 0.036). The expression level of Ki-67 was higher in infiltrative carcinomatous change than in carcinomatous change confined within duct (P = 0.006). The three-year and five-year disease-free survival rates were not significantly different between these two pathological types (P > 0.05). Conclusion: In carcinomatous change of breast intraductal papilloma, the patients with infiltrative carcinomatous change have a lower rate of nipple discharge and a higher expression level of Ki-67. Early detection and early diagnosis are essential to the treatment of carcinomatous change of breast intraductal papilloma and may improve its prognosis. Copyright © 2013 by TUMOR.